Strategy for Evaluating Evidence of Low-Dose Toxicity from Endocrine Active Chemicals

Identifying toxic chemicals is important for safeguarding human health. This report outlines a strategy to improve regulators’ ability to evaluate concerns that certain chemicals might cause hormone-related health effects at low doses. Two evaluation approaches of the strategy—systematic review and evidence integration—are demonstrated with data from animals and humans on two classes of endocrine active chemicals. These examples illustrate cases where the evidence supports low-dose effects in people.